7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Name:7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
CAS No.:1447305-24-9
Molecular Formula:C₃₀H₃₇N₃O₃
Molecular Weight:487.642
Hs Code.:

Synonyms:7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Property of 7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Technology Process of 7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

There total 5 articles about 7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 3990-05-4
ethyl 6-formylhexanoate

: 1447307-09-6
8-methyl-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-ol

: 1447305-24-9
7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: ethyl 6-formylhexanoate; 8-methyl-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-ol; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

methanol;

With water; sodium hydroxide; In ethanol; at 20 ℃; Inert atmosphere;

Reference yield:

: 1447307-10-9
tert-butyl 8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

: 1447305-24-9
7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere

1.2: 18 °C / Inert atmosphere

2.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

4.2: Isolute ? SCX-2 SPE

4.3: 20 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1447307-11-0
tert-butyl 8-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

: 1447305-24-9
7-(8-methoxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

3.2: Isolute ? SCX-2 SPE

3.3: 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane;