2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Base Information

Chemical Name:2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate
CAS No.:1365635-08-0
Molecular Formula:C₂₃H₃₂N₃O₉PS
Molecular Weight:557.562
Hs Code.:

Synonyms:2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Suppliers and Price of 2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

There total 3 articles about 2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.2%

: 1365255-67-9
(O-phenyl-N-(S)-1-(isopropoxycarbonyl)eth-1-yl)thiophosphoramidic chloride

: 1365635-07-9
C₁₁H₁₆N₂O₆

: 1365635-08-0
2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 70 ℃; for 1h;

Reference yield:

: 31448-54-1
2'-C-methyluridine

: 1365635-08-0
2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 20 °C / Cooling with ice; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 4 h / 0 °C

3.1: ammonium fluoride / methanol / 12 h / 80 °C

4.1: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 70 °C

With pyridine; 1-methyl-1H-imidazole; ammonium fluoride; sodium hydride; In tetrahydrofuran; methanol;

Reference yield:

: 159534-54-0
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-C-β-methyluridine

: 1365635-08-0
2'-C-2'-O-dimethyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4 h / 0 °C

2.1: ammonium fluoride / methanol / 12 h / 80 °C

3.1: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 70 °C

With 1-methyl-1H-imidazole; ammonium fluoride; sodium hydride; In tetrahydrofuran; methanol;