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31448-54-1

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31448-54-1 Usage

Applications

There are two main applications of 2'-C-methyluridine, which are targeted at hepatitis C and leukemia.2′-C-methyluridine is one of the key intermediates in the synthesis of nucleoside anti-hepatitis C and anti-leukemia drugs.

Uses

Different sources of media describe the Uses of 31448-54-1 differently. You can refer to the following data:
1. A 2’C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity.
2. A 2’-C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity.

Check Digit Verification of cas no

The CAS Registry Mumber 31448-54-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,4,4 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 31448-54:
(7*3)+(6*1)+(5*4)+(4*4)+(3*8)+(2*5)+(1*4)=101
101 % 10 = 1
So 31448-54-1 is a valid CAS Registry Number.

31448-54-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 2'-C-methyl uridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31448-54-1 SDS

31448-54-1Relevant articles and documents

Synthesis process of (2R')-2'-deoxyl-2'-fluoro-2'-methyluridine

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Paragraph 0022; 0026; 0055, (2018/09/13)

The invention discloses a synthesis process of (2R')-2'-deoxyl-2'-fluoro-2'-methyluridine, relates to the technical field of synthesis of medicines, and solves the technical problems of high cost andlow product yield of the existing process. According to the synthesis process, sodium borohydride or potassium borohydride is used for reducing ribose lactone, so that an expensive reductive reagent which is sodium dihydro-bis-(2-methoxyethoxy)aluminate or lithium tri-tert-butoxyaluminum hydride is not used, and the cost is greatly reduced; N,O-bis(trimethylsilyl)acetamide is used as a silicon etherification reagent, so that the yield of glycosylation reaction is increased; the product yield can reach 85-90% and is far higher than that in route III by 58%; the product yield is obviously increased; hydroxyl at the 5' site is protected, so that side reaction in ring-closing reaction can be avoided; meanwhile, a common polar solvent which is dimethylformamide is used; the product yield undercatalysis of sodium hydrogen carbonate can reach 87-92%. The synthesis process is easy to operate; the process condition is more easily controlled; the cost is reduced; the synthesis process is applicable to large-batch production.

A (2 'R) -2' - deoxy -2 '- fluoro -2' - methyl urea glucoside preparation method (by machine translation)

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Paragraph 0043, (2017/02/28)

The invention discloses a (2 'R) -2' - deoxy -2 '- fluoro -2' - methyl urea glucoside (type I) synthetic method. Cheap and easily available starting material, through the hydroxyl protection, cyclization, the links such as fluoride, obtains the type I compound. (by machine translation)

NMR-based conformational analysis of 2′,6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

Da Paix?o Soares, Fábio,Groaz, Elisabetta,Lescrinier, Eveline,Neyts, Johan,Leyssen, Pieter,Herdewijn, Piet

, p. 5809 - 5815 (2015/11/11)

Six novel phosphoramidate prodrugs of uridine analogues, with structural modifications introduced at the 6- and 2′,6-positions, have been prepared and evaluated for selective antiviral activity against hepatitis C virus, as well as other positive-stranded RNA viruses. An analysis of the conformational properties of the parent nucleosides was carried out using two-dimensional NMR spectroscopy based experiments, highlighting a 3′-endo (North) sugar puckering preference and syn orientation.

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