(S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide

Base Information

• Chemical Name: (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide
• CAS No.: 241126-54-5
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Mol file: 241126-54-5.mol

Synonyms:(S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide

Chemical Property of (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide

There total 2 articles about (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(2S)-2-phenylglycinol (20989-17-7) + 3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid chloride (241126-52-3) → (R)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide + (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide (241126-54-5)

Guidance literature:

DOI:10.1021/jf981245m

Reference yield:

3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (19353-25-4) → (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide (241126-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / SOCl₂

2: 25 percent

With thionyl chloride; 1: Substitution / 2: Condensation;

DOI:10.1021/jf981245m

Reference yield: 56.0%

methanol (67-56-1) + (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid (S)-phenylglycinol amide (241126-54-5) → (S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid methyl ester (241126-55-6)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; for 18h; Heating;

DOI:10.1021/jf981245m

upstream raw materials:

(2S)-2-phenylglycinol

3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid chloride

3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid

Downstream raw materials:

(S)-3,6-dihydro-4-methyl-2H-pyran-2-carboxylic acid methyl ester

(2S,4R)-4-methyl-2-(2-methyl-1-propenyl)tetrahydropyran