4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde

Base Information

• Chemical Name: 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde
• CAS No.: 741252-19-7
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.324
• Mol file: 741252-19-7.mol

Synonyms:4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde

Chemical Property of 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde

There total 1 articles about 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-methyl-piperazine (109-01-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + vanillin (121-33-5,8014-42-4) → 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde (741252-19-7)

Guidance literature:

In ethanol; water; for 18h; Reflux;

DOI:10.1016/j.carres.2010.06.005

Reference yield: 85.0%

1,3-dimethylbarbituric acid (769-42-6) + 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde (741252-19-7) → 5-(4-hydroxy-3-methoxy-5-((4-methylpiperazin-1-yl)methyl)benzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:

In ethanol; for 2h; Reflux;

DOI:10.1016/j.bioorg.2020.104198

Reference yield: 67.0%

4-imino-6-phenylfuro[2,3-d]pyrimidin-3(4H)-amine + 4-hydroxy-3-methoxy-5-[(4-methylpiperazin-1-yl)methyl] benzaldehyde (741252-19-7) → 4-(((4-imino-6-phenylfuro[2,3-d]pyrimidin-3(4H)-yl)imino)methyl)-2-methoxy-6-((4-methylpiperazin-1-yl)methyl)phenol

Guidance literature:

With acetic acid; In ethanol; for 4h; Reflux;

DOI:10.1016/j.bioorg.2021.105336

upstream raw materials:

1-methyl-piperazine

formaldehyd

vanillin