Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

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Chemical Name:Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester
CAS No.:368878-54-0
Molecular Formula:C₁₇H₂₂IN₅O₈S
Molecular Weight:583.361
Hs Code.:

Synonyms:Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

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Chemical Property of Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

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Technology Process of Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

There total 6 articles about Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 368878-54-0
Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Na₂CO₃ / CH₂Cl₂; H₂O / 1 h / 20 °C

2: 14.13 g / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 74 percent / NaH / tetrahydrofuran / 4 h / 20 °C

4: 98 percent / NaN₃ / dimethylformamide / 8 h / 90 °C

5: Dowex 50X₈-200 / methanol; H₂O / 48 h / 20 °C

6: 70 percent / PPh₃; CI₄ / tetrahydrofuran / 18 h / 20 °C

7: 95 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; sodium azide; carbon tetraiodide; Dowex 50X₈-200; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00650-0

Reference yield:

: 368878-37-9
1,2-dideoxy-3,4:5,6-di-O-isopropylidene-1,2-(N-p-nitrobenzenesulfonyl)imino-D-mannitol

: 368878-54-0
Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / NaN₃ / dimethylformamide / 8 h / 90 °C

2: Dowex 50X₈-200 / methanol; H₂O / 48 h / 20 °C

3: 70 percent / PPh₃; CI₄ / tetrahydrofuran / 18 h / 20 °C

4: 95 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; sodium azide; carbon tetraiodide; Dowex 50X₈-200; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00650-0

Reference yield:

: N-[(S)-2-Hydroxy-2-((4R,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethyl]-4-nitro-benzenesulfonamide

: 368878-54-0
Acetic acid (S)-1-{(4S,5R)-5-[(R)-2-azido-1-(4-nitro-benzenesulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-iodo-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 14.13 g / pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 74 percent / NaH / tetrahydrofuran / 4 h / 20 °C

3: 98 percent / NaN₃ / dimethylformamide / 8 h / 90 °C

4: Dowex 50X₈-200 / methanol; H₂O / 48 h / 20 °C

5: 70 percent / PPh₃; CI₄ / tetrahydrofuran / 18 h / 20 °C

6: 95 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; sodium azide; carbon tetraiodide; Dowex 50X₈-200; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00650-0