6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

Base Information

Chemical Name:6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one
CAS No.:959839-30-6
Molecular Formula:C₂₁H₂₅FN₄O₃
Molecular Weight:400.453
Hs Code.:

Synonyms:6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

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Chemical Property of 6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

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Technology Process of 6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

There total 5 articles about 6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959839-24-8
4-{5-[(5-Ethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}-1,4-diazepan-1-ium trifluoroacetate

: 75-36-5
acetyl chloride

: 959839-30-6
6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

Guidance literature:: 4-{5-[(5-Ethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}-1,4-diazepan-1-ium trifluoroacetate; acetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 0.666667h;

Reference yield:

: 959841-43-1
5-[(5-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoic Acid

: 959839-30-6
6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 20 °C

2.1: hydrogenchloride; ethanol / 1 h / 20 °C

2.2: pH 9

3.1: water; acetonitrile

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 0.67 h / 20 °C

With hydrogenchloride; ethanol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1154868-49-1
C₂₄H₃₁FN₄O₄

: 959839-30-6
6-{3-[(4-Acetyl-1,4-diazepan-1-yl)carbonyl]-4-fluorobenzyl}-4-ethylpyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; ethanol / 1 h / 20 °C

1.2: pH 9

2.1: water; acetonitrile

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 0.67 h / 20 °C

With hydrogenchloride; ethanol; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;