N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

Base Information

Chemical Name:N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide
CAS No.:80471-21-2
Molecular Formula:C₂₄H₃₅NO₅
Molecular Weight:417.546
Hs Code.:

Synonyms:N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

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Chemical Property of N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

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Technology Process of N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

There total 5 articles about N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 98-88-4
benzoyl chloride

: 71960-84-4,80513-57-1,80513-58-2
(7SR,9RS)-9-methyl-7-<(2-methyl-1,3-dioxolan-2-yl)methyl>-1,4-dioxaspiro<4.5>decane-6-propanamine

: 80471-21-2
N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

Guidance literature:: With triethylamine; In benzene; for 12h; Ambient temperature;
DOI:10.1021/ja00368a024

Reference yield:

: 69060-78-2
2-(2-cyanoethyl)-5-methylcyclohex-2-en-1-one

: 80471-21-2
N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / titanium tetrachloride / CH₂Cl₂ / 0.5 h / -78 °C

2: 83 percent / O₃ / methanol / 0.28 h / -78 °C

3: 99 percent / p-TsOH*H₂O / benzene / 6 h / Heating

4: 97.5 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

5: 98 percent / Et₃N / benzene / 12 h / Ambient temperature

With lithium aluminium tetrahydride; titanium tetrachloride; toluene-4-sulfonic acid; ozone; triethylamine; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00368a024

Reference yield:

: 80471-49-4,80471-50-7
(4RS,6SR)-4-methyl-6-<2-(2-methyl)propenyl>-2-oxocyclohexanepropanenitrile

: 80471-21-2
N-{3-[(7R,9S)-9-Methyl-7-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-propyl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / O₃ / methanol / 0.28 h / -78 °C

2: 99 percent / p-TsOH*H₂O / benzene / 6 h / Heating

3: 97.5 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

4: 98 percent / Et₃N / benzene / 12 h / Ambient temperature

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; ozone; triethylamine; In methanol; diethyl ether; benzene;
DOI:10.1021/ja00368a024