1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

Base Information

Chemical Name:1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester
CAS No.:127394-49-4
Molecular Formula:C₂₁H₁₈F₃NO₃
Molecular Weight:389.374
Hs Code.:

Synonyms:1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

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Chemical Property of 1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

There total 1 articles about 1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 94242-51-0
1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

: phenylmagnesium chloride

: 127394-49-4
1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: With copper(l) iodide; In diethyl ether; at -10 ℃;
DOI:10.1002/jhet.5570260630

Reference yield:

: 127394-49-4
1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 127394-56-3
1-cyclopropyl-6,7,8-trifluoro-2-phenyl-4(1H)-quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium hydride, phenylselenyl chloride, 2.) hydrogen peroxide / 1.) THF, 2.) CH₂Cl₂, H₂O, 25-30 deg C, 30 min

2: 34 percent / hydrochloric acid, acetic acid, water / 8 h / Heating

With hydrogenchloride; Phenylselenyl chloride; water; dihydrogen peroxide; sodium hydride; acetic acid;
DOI:10.1002/jhet.5570260630

Reference yield:

: 127394-49-4
1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 127394-61-0
1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium hydride, phenylselenyl chloride, 2.) hydrogen peroxide / 1.) THF, 2.) CH₂Cl₂, H₂O, 25-30 deg C, 30 min

2: triethylamine / acetonitrile / 48 h / Heating

With Phenylselenyl chloride; dihydrogen peroxide; sodium hydride; triethylamine; In acetonitrile;
DOI:10.1002/jhet.5570260630