1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt

Base Information

Chemical Name:1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt
CAS No.:127394-63-2
Molecular Formula:C₂₃H₂₀F₂N₃O₃*Na
Molecular Weight:447.417
Hs Code.:

Synonyms:

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Chemical Property of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt

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Technology Process of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt

There total 6 articles about 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94242-51-0
1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 127394-63-2
1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / cuprous iodide / diethyl ether / -10 °C

2: 1.) sodium hydride, phenylselenyl chloride, 2.) hydrogen peroxide / 1.) THF, 2.) CH₂Cl₂, H₂O, 25-30 deg C, 30 min

3: triethylamine / acetonitrile / 48 h / Heating

4: sodium hydroxide, water / tetrahydrofuran; ethanol / 1.5 h / Heating

With sodium hydroxide; copper(l) iodide; Phenylselenyl chloride; water; dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; acetonitrile;
DOI:10.1002/jhet.5570260630

Reference yield:

: phenylmagnesium chloride

: 127394-63-2
1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / cuprous iodide / diethyl ether / -10 °C

2: 1.) sodium hydride, phenylselenyl chloride, 2.) hydrogen peroxide / 1.) THF, 2.) CH₂Cl₂, H₂O, 25-30 deg C, 30 min

3: triethylamine / acetonitrile / 48 h / Heating

4: sodium hydroxide, water / tetrahydrofuran; ethanol / 1.5 h / Heating

With sodium hydroxide; copper(l) iodide; Phenylselenyl chloride; water; dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; acetonitrile;
DOI:10.1002/jhet.5570260630

Reference yield:

: 127394-49-4
1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 127394-63-2
1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-2-phenyl-7-(1-piperazinyl)-3-quinolinecarboxylic acid, sodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride, phenylselenyl chloride, 2.) hydrogen peroxide / 1.) THF, 2.) CH₂Cl₂, H₂O, 25-30 deg C, 30 min

2: triethylamine / acetonitrile / 48 h / Heating

3: sodium hydroxide, water / tetrahydrofuran; ethanol / 1.5 h / Heating

With sodium hydroxide; Phenylselenyl chloride; water; dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1002/jhet.5570260630