(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

Base Information

Chemical Name:(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene
CAS No.:203795-51-1
Molecular Formula:C₄₉H₆₅N₉O₄
Molecular Weight:844.113
Hs Code.:

(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

Synonyms:(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

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Chemical Property of (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

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Technology Process of (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

There total 7 articles about (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 203795-61-3
Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester

: 203795-51-1
(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

Guidance literature:: With sodium azide; In dimethyl sulfoxide;
DOI:10.1021/ja973881r

Reference yield:

: 1448-36-8
methyl cholate

: 203795-51-1
(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

3: 96 percent / NaH / tetrahydrofuran

4: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH

5: NaBH₄

6: 78 percent / Et₃N / CH₂Cl₂

7: 66 percent / NaN₃ / dimethylsulfoxide

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; dimethylsulfide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r

Reference yield:

: 3758-71-2
3α,7α,12α-trihydroxycholan-24-ol

: 203795-51-1
(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / Et₃N / dimethylformamide

2: 96 percent / NaH / tetrahydrofuran

3: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH

4: NaBH₄

5: 78 percent / Et₃N / CH₂Cl₂

6: 66 percent / NaN₃ / dimethylsulfoxide

With sodium tetrahydroborate; sodium azide; dimethylsulfide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r