Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester
• CAS No.: 203795-61-3
• Molecular Formula: C₅₂H₇₄O₁₃S₃
• Molecular Weight: 1003.35

Synonyms:Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester

Chemical Property of Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester

There total 6 articles about Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanesulfonyl chloride (124-63-0) + 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-Bis-(2-hydroxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethanol (203795-57-7) → Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester (203795-61-3)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/ja973881r

Reference yield:

methyl cholate (1448-36-8) → Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester (203795-61-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

3: 96 percent / NaH / tetrahydrofuran

4: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH

5: NaBH₄

6: 78 percent / Et₃N / CH₂Cl₂

With sodium tetrahydroborate; lithium aluminium tetrahydride; dimethylsulfide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja973881r

Reference yield:

3α,7α,12α-trihydroxycholan-24-ol (3758-71-2) → Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester (203795-61-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / Et₃N / dimethylformamide

2: 96 percent / NaH / tetrahydrofuran

3: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH

4: NaBH₄

5: 78 percent / Et₃N / CH₂Cl₂

With sodium tetrahydroborate; dimethylsulfide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja973881r

upstream raw materials:

methanesulfonyl chloride

2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-Bis-(2-hydroxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethanol

3α,7α,12α-trihydroxycholan-24-ol

methyl cholate

Downstream raw materials:

N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(2-azido-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(2-amino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 203795-61-3 Methanesulfonic acid 2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-methanesulfonyloxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send