3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

Base Information

Chemical Name:3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde
CAS No.:1027553-42-9
Molecular Formula:C₃₈H₄₉NO₉
Molecular Weight:663.808
Hs Code.:

Synonyms:3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

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Chemical Property of 3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

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Technology Process of 3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

There total 4 articles about 3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136590-83-5
3,5-dichloropyridine-4-carboxaldehyde

: 251996-74-4
4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenol

: 1027553-42-9
3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

Guidance literature:: 4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenol; With potassium tert-butylate; In tetrahydrofuran; at 25 ℃; for 1h;

3,5-dichloropyridine-4-carboxaldehyde; In tetrahydrofuran; at 70 ℃; for 2h; Further stages.;
DOI:10.1021/jm0101702

Reference yield:

: 16728-03-3
1-(4-Methoxyphenyl)cyclopropyl-1-carbinol

: 1027553-42-9
3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH; 15-crown-5 / tetrahydrofuran / 0.25 h / 20 °C

1.2: 95 percent / tetrahydrofuran / 5 h / 20 °C

2.1: 93 percent / sodium thioethoxide / dimethylformamide / 5 h / 145 °C

3.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 25 °C

3.2: tetrahydrofuran / 2 h / 70 °C

With 15-crown-5; sodium thioethoxide; potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0101702

Reference yield:

: 54176-27-1
2-(2-ethoxyethoxy)ethyl tosylate

: 1027553-42-9
3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH; 15-crown-5 / tetrahydrofuran / 0.25 h / 20 °C

1.2: 95 percent / tetrahydrofuran / 5 h / 20 °C

2.1: 93 percent / sodium thioethoxide / dimethylformamide / 5 h / 145 °C

3.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 25 °C

3.2: tetrahydrofuran / 2 h / 70 °C

With 15-crown-5; sodium thioethoxide; potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0101702