54176-27-1

Upstream product

• 111-90-0 ethoxyethoxyethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 133146-42-6 2-{(1R,3S,4S)-3,4-Bis-[2-(2-ethoxy-ethoxy)-ethoxy]-cyclohexyl}-2-methyl-[1,3]dioxolane 
• 113983-89-4 trans-1,2-bis(1,4,7-trioxanonyl)cyclohexane 
• 123-91-1 1,4-dioxane 
• 251996-73-3 4-{1-[[2-(2-ethoxyethoxy)ethoxy]methyl]cyclopropyl}anisole 
• 90688-48-5 4-[2-(2-ethoxy-ethoxy)-ethoxy]-phenylamine 
• 939374-70-6 C₂₂H₃₄O₁₀ 
• 1227930-91-7 2-iodo-9,9-di(2-(2-ethoxyethoxy)ethyl)fluorene 
• 98596-86-2 (4-Acetamino-2-propionyl-phenyl)-<2-(2-ethoxy-ethoxy)-ethyl>-ether 
• 4863-15-4 3-Jod-5-pentyloxycarbonyl-benzoesaeure-<2-(2-aethoxy-aethoxy)-aethylester> 
• 5008-29-7 3-Jod-5-butoxycarbonyl-benzoesaeure-<2-(2-aethoxy-aethoxy)-aethylester> 
• 4863-03-0 3-Jod-5-propoxycarbonyl-benzoesaeure-<2-(2-aethoxy-aethoxy)-aethylester> 
• 4842-25-5 3-Jod-5-aethoxycarbonyl-benzoesaeure-<2-(2-aethoxy-aethoxy)-aethylester> 
• 4842-17-5 3-Jod-5-methoxycarbonyl-benzoesaeure-<2-(2-aethoxy-aethoxy)-aethylester> 
• 54646-23-0 5-(N,N-Dibenzylglycyl)-2-[2-(2-ethoxyethoxy)ethoxy] benzamide 

Relevant academic research and scientific papers

Dynamic dye emission ON/OFF systems by a furan moiety exchange protocol

Four triphenylamine-based dyes were synthesized by fluorescence turn on reactions. Optical behaviours, molecular arrangements, donor-to-acceptor charge transfer and dipole interactions of these functional dyes were investigated by UV–vis absorption and fluorescence spectroscopy, single-crystal X-ray diffraction and electrochemical cyclic voltammetry. The irreversible isomerization of itaconimide dye leads to an irreversible emission switch ON to OFF. Reversible Diels-Alder reaction of these dyes lead to a reversible emission switch OFF/ON. These luminescent dyes demonstrate dynamic dye molecular features by furan moiety exchanges to form energy-minimized and optimized dye molecular structures. In the dynamic molecular system, α-position furan-substituted dye was converted into more stable β-position furan-substituted dye according to 1H NMR spectroscopic monitoring.

Synthesis preparation method of fluorene-based compound with 4-position substituent

The invention discloses a synthesis preparation method of a fluorene-based compound with 4-position substituent groups. The method is simple in step and convenient to control, is suitable for small preparation of laboratories, and is also suitable for ind

PROGNOSTIC BIOMARKERS FOR TTK INHIBITOR CHEMOTHERAPY

The present invention provides a method for identifying a tumor - in a human individual or in an animal - that is susceptible to treatment with a TTK inhibitor, said method comprising: a] providing a sample of a tumor; b] determining the presence of a mutated CTNNB1 gene in said tumor sample, wherein said mutation is located in exon 3 of CTNNB1 and whereby the presence of a mutated CTNNB1 gene indicates that the tumor is susceptible to treatment with a TTK inhibitor. In an alternative aspect, step b] of the above defined method is replaced by the step of determining the presence of a mutated CTNNB1 protein in said tumor sample, wherein said mutation is located in exon 3 of CTNNB1 and whereby the presence of a mutated CTNNB1 protein indicates that the tumor is susceptible to treatment with a TTK inhibitor. In a further alternative, step b] comprises determining an altered expression of a CTNNB1 regulated gene, whereby an altered expression of a CTNNB1 regulated gene indicates that the tumor is susceptible to treatment with a TTK inhibitor.

Glucopyranosyl derivative and application thereof in medicines

The invention relates to a glucopyranosyl derivative used as a sodium-dependent glucose transporter (SGLT) inhibitor, a medicinal composition containing the derivative, and an application of the derivative and the medicinal composition in medicines, and especially relates to the glucopyranosyl derivative represented by formula (I) or a pharmaceutically acceptable salt or all stereoisomers thereof, or the medicinal composition containing the derivative, and a use of the derivative and the medicinal composition in the preparation of medicines for treating diabetes and diabetes related diseases.

MONOMERS AND POLYMERS DERIVED FROM NATURAL PHENOLS

Monomers, polymers and copolymers are provided that incorporate at least one naturally occurring phenolic compound, such as a plant phenol, as well as methods for producing the monomers and polymers. Plant phenols possessing a reactive group in addition t

Dynamic Covalent Assembly of Peptoid-Based Ladder Oligomers by Vernier Templating

Dynamic covalent chemistry, in conjunction with template-directed assembly, enables the fabrication of extended nanostructures that are both precise and tough. Here we demonstrate the dynamic covalent assembly of peptoid-based molecular ladders with up to 12 rungs via scandium(III)-catalyzed imine metathesis by employing the principle of Vernier templating, where small precursor units with mismatched numbers of complementary functional groups are coreacted to yield larger structures with sizes determined by the respective precursor functionalities. Owing to their monomer diversity and synthetic accessibility, sequence-specific oligopeptoids bearing dynamic covalent pendant groups were employed as precursors for molecular ladder fabrication. The generated structures were characterized using matrix-assisted laser desorption/ionization mass spectrometry and gel permeation chromatography, confirming successful molecular ladder fabrication.

(5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOLIZINES

The invention relates to a compound of Formula (I) wherein, R1 and R2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and (1-5C)heteroaryl groups. The compounds can be used in pharmaceutical compositions, in particular in the treatment of cancer.

Soluble and reusable poly(norbornene) supports with high loading capacities for peptide synthesis

Poly(norbornene) supports comprising solubilizing ethylene glycol units and multiple amino acid attachment sites have been developed for peptide synthesis. A variety of amino acids have been efficiently loaded (0.6-1.1 mmol/g) onto the support in high yields (83-98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41-66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.

4′-(2-(2-Ethoxyethoxy)ethoxy)biphenyl-4-carboxylic acid-a polar smectogen for amphipathic liquid crystals

We describe a new calamitic smectogen and some of its esters with a three-block molecular architecture (polar oxyethylene chain, rigid biphenyl and non-polar aliphatic chain) which were characterised by a combination of optical, thermical, X-ray and computational techniques. The title compound is a valuable smectogenic building block for amphipathic functional organic materials.

Synthesis of penta-p-phenylenes with oligo(ethylene glycol) side chains

We report an efficient synthesis of a series of penta-p-phenylene derivatives with four side chains of various lengths, including deca(ethylene glycol) groups. The key feature of the synthesis is that the side chains are efficiently introduced in the last step, facilitating optimization of the side chains for different applications. Raman spectroscopy study indicates a similarly high rigidity for all these compounds, even those with long oligo(ethylene glycol) side chains. The deca(ethylene glycol)-substituted penta-p-phenylene derivatives are versatile building blocks for construction of nanometric, tripod-shaped adsorbates for biological applications.