trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

Base Information

Chemical Name:trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid
CAS No.:148133-92-0
Molecular Formula:C₂₃H₂₅ClFNO₃*ClH
Molecular Weight:454.369
Hs Code.:

Synonyms:trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

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Chemical Property of trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

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Technology Process of trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

There total 5 articles about trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 148903-20-2
4-(4-Fluorphenylmethyl)-3-methylen-4,5-dihydro-2(3H)-furanon

: 142001-84-1
4-(4-hydroxyphenyl)-4-hydroxypiperidine

: 148133-92-0
trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

Guidance literature:: With acetic acid; In diethyl ether; ethanol; for 48h; Ambient temperature;
DOI:10.1002/ardp.19933260111

Reference yield:

: 81198-14-3
4-(4-Fluorbenzoyl)-4,5-dihydro-2(3H)-furanon

: 148133-92-0
trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / hydrogen / Pd/C / acetic acid / 760 Torr / Ambient temperature

2: 57 percent / dimethylformamide / 6 h / 140 °C

3: 53 percent / 30 percent aq. formaldehyde, diethylamine, sodium acetate / acetic acid / 1.) r.t., 5 min, 2.) heating (water bath), 10 min

4: 65 percent / acetic acid / ethanol; diethyl ether / 48 h / Ambient temperature

With formaldehyd; hydrogen; sodium acetate; acetic acid; diethylamine; palladium on activated charcoal; In diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19933260111

Reference yield:

: 366-77-8
4-(4-fluorophenyl)-4-oxopropionic acid

: 148133-92-0
trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 20 percent aq. K₂CO₃, 2.) konz. HCl / 1.) r.t., 14 d, 2.) heating (water bath), 30 min

2: 85 percent / hydrogen / Pd/C / acetic acid / 760 Torr / Ambient temperature

3: 57 percent / dimethylformamide / 6 h / 140 °C

4: 53 percent / 30 percent aq. formaldehyde, diethylamine, sodium acetate / acetic acid / 1.) r.t., 5 min, 2.) heating (water bath), 10 min

5: 65 percent / acetic acid / ethanol; diethyl ether / 48 h / Ambient temperature

With hydrogenchloride; formaldehyd; hydrogen; sodium acetate; potassium carbonate; acetic acid; diethylamine; palladium on activated charcoal; In diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19933260111