5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid

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Chemical Name:5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid
CAS No.:1234015-53-2
Molecular Formula:CH₂O₂*C₁₈H₁₉N₇O₂
Molecular Weight:411.42
Hs Code.:

Synonyms:5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid

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Chemical Property of 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid

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Technology Process of 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid

There total 2 articles about 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.5%

: 64-18-6
formic acid

: 1234015-59-8
5-isothiocyanatopyrazine-2-carbonitrile

: 1234015-60-1
tert-butyl 3-(2-acetyl-3-methoxyphenoxy)propylcarbamate

: 1234015-53-2
5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid

Guidance literature:: tert-butyl 3-(2-acetyl-3-methoxyphenoxy)propylcarbamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.166667h;

5-isothiocyanatopyrazine-2-carbonitrile; In tetrahydrofuran; at 30 ℃;

formic acid; Further stages;

Reference yield:

: 703-23-1
2'-hydroxy-6'-methoxyacetophenone

: 1234015-53-2
5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile formic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C

2.2: 30 °C

With di-isopropyl azodicarboxylate; lithium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran;