N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

Base Information

Chemical Name:N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide
CAS No.:359878-07-2
Molecular Formula:C₂₁H₂₅FN₂O
Molecular Weight:340.441
Hs Code.:

Synonyms:N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

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Chemical Property of N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

Chemical Property:

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Technology Process of N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

There total 5 articles about N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₃FN₂O₃

: 359878-07-2
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 2h;

Reference yield:

: 359877-52-4
tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate

: 459-04-1
4-Fluorophenylacetyl chloride

: 359878-07-2
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

Guidance literature:: tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate; 4-Fluorophenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

In dichloromethane; water; for 2h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 359878-07-2
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-fluorophenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium cyanoborohydride / methanol / 20 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;