(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

Base Information

Chemical Name:(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone
CAS No.:180633-71-0
Molecular Formula:C₂₆H₃₀IN₃O₆SSi
Molecular Weight:667.597
Hs Code.:

Synonyms:(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

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Chemical Property of (1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

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Technology Process of (1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

There total 5 articles about (1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 180633-69-6
(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanol

: 180633-71-0
(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1016/0040-4039(96)01148-3

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 180633-71-0
(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide; tetrahydrofuran / 2 h

2: 1.) t-BuLi / 1.) THF, -90 deg C, 30 min; 2.) THF, -78 deg C to 0 deg C, 4 h

3: 92 percent / MnO₂ / CH₂Cl₂ / 4 h / Ambient temperature

With manganese(IV) oxide; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)01148-3

Reference yield:

: 180633-65-2
6-methoxymethoxy-1H-indole

: 180633-71-0
(1-benzenesulfonyl-6-methoxymethoxy-1H-indol-3-yl)-[4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: KOH, I₂ / dimethylformamide / Ambient temperature

2: NaH / dimethylformamide; tetrahydrofuran / 2 h

3: 1.) t-BuLi / 1.) THF, -90 deg C, 30 min; 2.) THF, -78 deg C to 0 deg C, 4 h

4: 92 percent / MnO₂ / CH₂Cl₂ / 4 h / Ambient temperature

With manganese(IV) oxide; potassium hydroxide; iodine; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)01148-3