(2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane

Base Information

Chemical Name:(2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane
CAS No.:1332506-77-0
Molecular Formula:C₁₉H₂₉FO₂Si
Molecular Weight:336.522
Hs Code.:

Synonyms:(2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane

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Chemical Property of (2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane

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Technology Process of (2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane

There total 2 articles about (2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1073277-42-5
(S)-(-)-1-(3'-fluorophenyl)prop-2-en-1-yl tert-butyl carbonate

: 119125-28-9,136917-96-9,136984-28-6
(R)-1-(tert-butyldimethylsilyloxy)but-3-en-2-ol

: 1332506-77-0
(2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane

Guidance literature:: (R)-1-(tert-butyldimethylsilyloxy)but-3-en-2-ol; With n-butyllithium; In tetrahydrofuran; pentane; at 0 ℃; for 0.25h; Inert atmosphere;

With copper(l) iodide; In tetrahydrofuran; pentane; at 20 ℃; for 0.5h; Inert atmosphere;

(S)-(-)-1-(3'-fluorophenyl)prop-2-en-1-yl tert-butyl carbonate; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; In tetrahydrofuran; pentane; at 0 - 20 ℃; for 16h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo201110z

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1332506-77-0
(2R,1'S)-tert-butyl(dimethyl)(2-(1'-(3''-fluorophenyl)allyloxy)-but-3-enyloxy)silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; pentane / 0.25 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

2.3: 16 h / 0 - 20 °C / Inert atmosphere

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; pentane;
DOI:10.1021/jo201110z