N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Base Information

Chemical Name:N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide
CAS No.:1262798-90-2
Molecular Formula:C₂₀H₂₁FN₆O₄
Molecular Weight:428.423
Hs Code.:

Synonyms:N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

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Chemical Property of N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

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Technology Process of N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

There total 9 articles about N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262799-36-9
tert-butyl ((4aS,5R,7aS)-7a-(5-amino-2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

: 1262798-90-2
N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1262799-51-8
[(2R,3R,4S)-4-amino-4-(2-fluoro-phenyl)-2-methyl-tetrahydro-furan-3-yl]-methanol

: 1262798-90-2
N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2.1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 °C

3.1: sulfuric acid / methanol / 20 °C / Inert atmosphere; Reflux

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

5.1: nitric acid / 20 - 50 °C

5.2: Ice-cooling

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate / dichloromethane / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With chromium(VI) oxide; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; sulfuric acid; hydrogen; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1262799-28-9
tert-butyl ((4aS,5R,7aS)-7a-(2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

: 1262798-90-2
N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid / 20 - 50 °C

1.2: Ice-cooling

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate / dichloromethane / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;