Technology Process of (5R,6R)-5-acetoxy-6-(benzyloxy)hexadecanal
There total 8 articles about (5R,6R)-5-acetoxy-6-(benzyloxy)hexadecanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / sodium hydride / tetrahydrofuran / 10 h / Heating
2: 82 percent / N-chlorossucinimide, sodium bicarbonate, silver nitrate / acetone; H2O / 0.17 h / Ambient temperature
3: diethyl ether / 1 h / -78 °C
4: 93 percent / 4-dimethylaminopyridine / Ambient temperature
5: 1.) ozone, 2.) dimethyl sulfide / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, RT, 1 h
With
dmap; N-chloro-succinimide; dimethylsulfide; sodium hydride; sodium hydrogencarbonate; ozone; silver nitrate;
In
tetrahydrofuran; diethyl ether; water; acetone;
DOI:10.1021/jo00376a056
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diethyl ether / 1 h / -78 °C
2: 93 percent / 4-dimethylaminopyridine / Ambient temperature
3: 1.) ozone, 2.) dimethyl sulfide / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, RT, 1 h
With
dmap; dimethylsulfide; ozone;
In
diethyl ether;
DOI:10.1021/jo00376a056
- Guidance literature:
-
Multi-step reaction with 6 steps
1: L-selectride, LiI / toluene / 4 h / -78 °C
2: 92 percent / sodium hydride / tetrahydrofuran / 10 h / Heating
3: 82 percent / N-chlorossucinimide, sodium bicarbonate, silver nitrate / acetone; H2O / 0.17 h / Ambient temperature
4: diethyl ether / 1 h / -78 °C
5: 93 percent / 4-dimethylaminopyridine / Ambient temperature
6: 1.) ozone, 2.) dimethyl sulfide / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, RT, 1 h
With
dmap; N-chloro-succinimide; dimethylsulfide; L-Selectride; sodium hydride; sodium hydrogencarbonate; ozone; silver nitrate; lithium iodide;
In
tetrahydrofuran; diethyl ether; water; acetone; toluene;
DOI:10.1021/jo00376a056
