methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Base Information

Chemical Name:methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate
CAS No.:1345870-52-1
Molecular Formula:C₂₇H₂₅Cl₂N₃O₃S
Molecular Weight:542.486
Hs Code.:

Synonyms:methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

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Chemical Property of methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

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Technology Process of methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

There total 5 articles about methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.4%

: 1345870-35-0
methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-8-(propylamino)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

: 1345870-52-1
methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Guidance literature:: With Lawessons reagent; In toluene; at 70 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.09.043

Reference yield:

: 1121-57-9
1-isocyanocyclohexene

: 1345870-52-1
methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C

1.2: 0 - 20 °C

1.3: 45 - 70 °C

2.1: acetic acid / methanol / 0.5 h / 20 °C / pH 6 - 7

2.2: 16 h / 20 °C

3.1: Lawessons reagent / toluene / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; acetic acid; potassium hydroxide; In methanol; toluene; 1.2: Ugi four component condensation;
DOI:10.1016/j.ejmech.2011.09.043

Reference yield:

: 1345870-34-9
methyl 2-(8-amino-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate

: 1345870-52-1
methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-8-(propylamino)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C / pH 6 - 7

1.2: 16 h / 20 °C

2.1: Lawessons reagent / toluene / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; acetic acid; In methanol; toluene;
DOI:10.1016/j.ejmech.2011.09.043