1345870-34-9Relevant academic research and scientific papers
Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53-MDM2 protein-protein interaction
Zhuang, Chunlin,Miao, Zhenyuan,Zhu, Lingjian,Zhang, Yongqiang,Guo, Zizhao,Yao, Jianzhong,Dong, Guoqiang,Wang, Shengzheng,Liu, Yang,Chen, Hai,Sheng, Chunquan,Zhang, Wannian
experimental part, p. 5654 - 5661 (2011/12/21)
A series of thio-benzodiazepine p53-MDM2 inhibitors were designed and synthesized based on the principle of bioisosterism. Most of the thio-benzodiazepines had nanomolar to micromolar affinity toward MDM2. Particularly, compounds 8a (Ki = 0.52
