2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

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Chemical Name:2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester
CAS No.:761433-05-0
Molecular Formula:C₄₁H₆₉ClINO₉Si₃
Molecular Weight:966.614
Hs Code.:

2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

Synonyms:2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

There total 2 articles about 2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 3282-30-2
pivaloyl chloride

: [(S)-1-(4-{(R)-1-[(1S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester

: 761433-05-0
2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

Guidance literature:: With dmap; triethylamine; at 20 ℃;
DOI:10.1016/j.tetlet.2004.06.136

Reference yield:

: 365450-43-7
(S)-3-tert-Butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propionic acid methyl ester

: 761433-05-0
2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIBAL-H / CH₂Cl₂ / -78 °C

1.2: 82 percent / NaBH₄ / ethanol / 0 °C

2.1: 100 percent / DMAP; Et₃N / 20 °C

With dmap; diisobutylaluminium hydride; triethylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2004.06.136

Reference yield:

: C₄₇H₆₄O₇Si₂

: 761433-05-0
2,2-Dimethyl-propionic acid (S)-3-tert-butoxycarbonylamino-3-(4-{(R)-1-[(1S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-1-trimethylsilanyloxy-cyclopent-2-enyl]-3-trimethylsilanyl-prop-2-ynyloxy}-3-chloro-5-methoxymethoxy-phenyl)-propyl ester

: C₈₈H₁₃₂ClNO₁₆Si₅

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetlet.2004.06.136