[18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Base Information

Chemical Name:[18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]
CAS No.:1355357-59-3
Molecular Formula:C₂₀H₂₂FNO
Molecular Weight:310.401
Hs Code.:

Synonyms:[18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Suppliers and Price of [18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Chemical Property:

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Technology Process of [18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

There total 6 articles about [18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355357-58-2
[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

: 1355357-59-3
[18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Guidance literature:: With potassium carbonate; [2.2.2]cryptande; In dimethyl sulfoxide; at 150 ℃; for 0.333333h;
DOI:10.1016/j.bmc.2011.11.002

Reference yield:

: 1355357-51-5
1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

: 1355357-59-3
[18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Guidance literature:: With [¹⁸F]-potassium fluoride; [2.2.2]cryptande; In dimethyl sulfoxide; at 150 ℃; for 0.416667h;
DOI:10.1002/cmdc.201600366

Reference yield:

: 477352-23-1
C₂₀H₂₀N₂O

: 1355357-59-3
[18F]1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; water / 19 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / -25 - 20 °C / Inert atmosphere

4: potassium carbonate; [2.2.2]cryptande / dimethyl sulfoxide / 0.33 h / 150 °C

With dmap; lithium aluminium tetrahydride; sulfuric acid; water; potassium carbonate; triethylamine; [2.2.2]cryptande; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.11.002