[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Base Information

Chemical Name:[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate
CAS No.:1355357-58-2
Molecular Formula:C₂₇H₂₉NO₄S
Molecular Weight:463.598
Hs Code.:

Synonyms:[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Suppliers and Price of [(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

There total 4 articles about [(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98-59-9
p-toluenesulfonyl chloride

: C₂₀H₂₃NO₂

: 1355357-58-2
[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at -25 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.11.002

Reference yield:

: 477352-23-1
C₂₀H₂₀N₂O

: 1355357-58-2
[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / 19 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / -25 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; sulfuric acid; water; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.11.002

Reference yield:

: 477352-24-2
1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

: 1355357-58-2
[(1'-benzyl-3H-spiro[[2]benzofuran-1,4'-piperidin]-3-yl)]-methyl tosylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / -25 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.11.002