2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

Base Information

Chemical Name:2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one
CAS No.:175883-01-9
Molecular Formula:C₂₂H₃₅BrO₃Si
Molecular Weight:455.508
Hs Code.:

Synonyms:2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

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Chemical Property of 2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

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Technology Process of 2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

There total 7 articles about 2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 175882-69-6
6-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohex-2-en-1-one

: 175883-01-9
2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h;
DOI:10.1021/jm950747d

Reference yield:

: 4694-17-1
5,5-dimethlycyclohex-2-en-1-one

: 175883-01-9
2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, RT, 3 h

2: 99 percent / H₂ / 5percent Pd/C / ethyl acetate / 24 h

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm950747d

Reference yield:

: 63272-66-2
4-bromo-2-hydroxy-5-methoxybenzaldehyde

: 175883-01-9
2-<<4-bromo-2-<(tert-butyldimethylsilyl)oxy>-5-methoxyphenyl>methyl>-5,5-dimethylcyclohexan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole, DMAP / CH₂Cl₂ / Ambient temperature

2: NaBH₄ / methanol / 0 °C

3: Ph₃P, Br₂ / dimethylformamide / 0 °C

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, RT, 3 h

5: 99 percent / H₂ / 5percent Pd/C / ethyl acetate / 24 h

With 1H-imidazole; dmap; sodium tetrahydroborate; hydrogen; bromine; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950747d