tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate
• CAS No.: 1263324-77-1
• Molecular Formula: C₂₀H₂₃N₃O₃
• Molecular Weight: 353.421
• Mol file: 1263324-77-1.mol

Synonyms:tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate

Chemical Property of tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate

There total 1 articles about tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C13H19N3O2 (1263324-67-9) + benzoyl chloride (98-88-4) → tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate (1263324-77-1)

Guidance literature:

C₁₃H₁₉N₃O₂; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; at -10 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tet.2010.11.057

Reference yield: 70.0%

tert-butyl 1-methyl-2-(3-oxo-3-phenyl-1-(pyridin-2-yl)propylidene)hydrazinecarboxylate (1263324-77-1) → 2-(1-methyl-5-phenyl-1H-pyrazol-3-yl)pyridine (1263324-79-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.11.057

upstream raw materials:

C₁₃H₁₉N₃O₂

benzoyl chloride

Downstream raw materials:

2-(1-methyl-5-phenyl-1H-pyrazol-3-yl)pyridine