(17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

Base Information

Chemical Name:(17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide
CAS No.:1609387-15-6
Molecular Formula:C₃₅H₅₀N₂O₄
Molecular Weight:562.793
Hs Code.:

Synonyms:(17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

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Chemical Property of (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

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Technology Process of (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

There total 3 articles about (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 1255359-09-1
(17β)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxylic acid

: 104-94-9
4-methoxy-aniline

: 1609387-15-6
(17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

: 1609387-16-7
C₂₈H₄₃NO₄

Guidance literature:: formaldehyd; 4-methoxy-aniline; In methanol; at 20 ℃; for 0.5h;

tert-butylisonitrile; (17β)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxylic acid; In methanol; at 20 ℃; for 72h; regioselective reaction;
DOI:10.1016/j.steroids.2014.03.002

Reference yield:

: 2681-55-2
3-oxo-androst-4-ene-17β-carboxylic acid methyl ester

: 1609387-15-6
(17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: potassium hydroxide / ethylene glycol / 0.33 h / Reflux

3.1: methanol / 0.5 h / 20 °C

3.2: 72 h / 20 °C

With potassium tert-butylate; potassium hydroxide; In tetrahydrofuran; methanol; ethylene glycol; 3.1: |Ugi Condensation / 3.2: |Ugi Condensation;
DOI:10.1016/j.steroids.2014.03.002

Reference yield:

: 1609387-14-5
C₂₃H₃₄O₃

: 1609387-15-6
(17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethylene glycol / 0.33 h / Reflux

2.1: methanol / 0.5 h / 20 °C

2.2: 72 h / 20 °C

With potassium hydroxide; In methanol; ethylene glycol; 2.1: |Ugi Condensation / 2.2: |Ugi Condensation;
DOI:10.1016/j.steroids.2014.03.002