Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Base Information

Chemical Name:Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline
CAS No.:86272-71-1
Molecular Formula:C₃₃H₄₀N₂O₁₀
Molecular Weight:624.688
Hs Code.:

Synonyms:Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Suppliers and Price of Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

There total 5 articles about Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 79816-35-6
3-benzyloxy-3-oxo-propanoic acid magnesium salt

: 86272-70-0
Methyl Ester of N-<3-<<3-Carboxy-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

: 86272-71-1
Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 5h;
DOI:10.1021/jo00164a010

Reference yield:

: 80089-24-3
benzyl prolinate hydrochloride

: 86272-71-1
Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Guidance literature:: Multi-step reaction with 4 steps

1: 46.5 percent / N-methylmorpholine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂

2: 1.) H₂ / 1.) Pd/C / 1.) 1h; 2.) ethyl acetate/methanol, diethyl ether

3: 1.) m-dimethoxybenzene; 2.) di-tert-butyl dicarbonate, 1N KHCO₃ / 1.) trifluoroacetic acid, 0 deg C, 3h; 2.) dioxane

4: 87 percent / N,N-carbonyldiimidazole / tetrahydrofuran / 5 h / 50 °C

With 4-methyl-morpholine; di-tert-butyl dicarbonate; hydrogen; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; 1,3-Dimethoxybenzene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00164a010

Reference yield:

: 86272-67-5
Benzylic Ester of N-<3-<<3-(tert-Butoxycarbonyl)-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

: 86272-71-1
Methyl Ester of N-<3-<<3-<1-Oxo-2-(benzyloxycarbonyl)ethyl>-4-methoxyphenyl>oxy>-N-(tert-butoxycarbonyl)-(2S,3S)-prolyl>-(S)-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂ / 1.) Pd/C / 1.) 1h; 2.) ethyl acetate/methanol, diethyl ether

2: 1.) m-dimethoxybenzene; 2.) di-tert-butyl dicarbonate, 1N KHCO₃ / 1.) trifluoroacetic acid, 0 deg C, 3h; 2.) dioxane

3: 87 percent / N,N-carbonyldiimidazole / tetrahydrofuran / 5 h / 50 °C

With di-tert-butyl dicarbonate; hydrogen; potassium hydrogencarbonate; 1,1'-carbonyldiimidazole; 1,3-Dimethoxybenzene; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jo00164a010