Technology Process of (6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypropan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-amine
There total 6 articles about (6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypropan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl [(6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypropan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]carbamate;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.666667h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 1.5 h / 2585.81 Torr
1.2: Chiral Pak.(R). AD.(R). column
2.1: Lawessons reagent / toluene / 16 h / 40 °C
3.1: mercury dichloride / ethanol / 0.33 h
4.1: dipyridinium dichromate / acetonitrile / 1.75 h / 70 °C
5.1: trifluoroacetic acid / dichloromethane / 0.67 h
With
Lawessons reagent; dipyridinium dichromate; hydrogen; trifluoroacetic acid; mercury dichloride;
20% palladium hydroxide-activated charcoal;
In
methanol; ethanol; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C
1.2: 0.83 h
2.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 1.5 h / 2585.81 Torr
2.2: Chiral Pak.(R). AD.(R). column
3.1: Lawessons reagent / toluene / 16 h / 40 °C
4.1: mercury dichloride / ethanol / 0.33 h
5.1: dipyridinium dichromate / acetonitrile / 1.75 h / 70 °C
6.1: trifluoroacetic acid / dichloromethane / 0.67 h
With
Lawessons reagent; dipyridinium dichromate; hydrogen; sodium hydride; trifluoroacetic acid; mercury dichloride;
20% palladium hydroxide-activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
![tert-butyl [(6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypropan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]carbamate](/Databaselist/images/loading.webp)
