N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

Base Information

Chemical Name:N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester
CAS No.:137393-05-6
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

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Chemical Property of N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

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Technology Process of N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

There total 6 articles about N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 37553-65-4
Boc-N-Me-Phe-OH

: 501-53-1,94274-21-2
benzyl chloroformate

: 137393-05-6
N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

Guidance literature:: With dmap; 4-(dimethylamino)pyridine hydrochloride; triethylamine; In dichloromethane; for 3h;
DOI:10.1021/jo00124a019

Reference yield: 49.0%

: 37553-65-4
Boc-N-Me-Phe-OH

: 100-51-6,185532-71-2
benzyl alcohol

: 137393-05-6
N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 15h; Ambient temperature;

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 137393-05-6
N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / 2-methyl-propan-2-ol

2: NaH / tetrahydrofuran

3: Li₂CO₃ / dimethylformamide

With lithium carbonate; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)01599-8