N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Base Information

Chemical Name:N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester
CAS No.:168070-03-9
Molecular Formula:C₃₄H₄₈N₂O₇
Molecular Weight:596.764
Hs Code.:

Synonyms:N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

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Technology Process of N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

There total 10 articles about N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 40298-25-7
(S)-2-Methylamino-3-phenyl-propionic acid benzyl ester; compound with toluene-4-sulfonic acid

: 160036-89-5
N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-OH

: 168070-03-9
N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Guidance literature:: With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
DOI:10.1016/S0960-894X(99)00038-4

Reference yield: 82.0%

: 47091-20-3
N-Methyl-L-phenylalanine phenylmethyl ester

: 160036-89-5
N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-OH

: 168070-03-9
N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Guidance literature:: With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at -10 ℃; for 10h;
DOI:10.1021/jo00124a019

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 168070-03-9
N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / PhI(OAc)2, I₂ / -10 °C

2: EDCI, DMAP, TEA

3: H₂ / 10 percent Pd/C / methanol; ethyl acetate

4: 84 percent / BOP-Cl, NMM

With 4-methyl-morpholine; dmap; [bis(acetoxy)iodo]benzene; TEA; hydrogen; iodine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(99)00038-4