Technology Process of (S)-2-phthalimido-6-methyl-6-hydroxyheptanoic acid, phenylmethyl ester
There total 6 articles about (S)-2-phthalimido-6-methyl-6-hydroxyheptanoic acid, phenylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / Cs2CO3 / dimethylformamide / 2 h / Ambient temperature
2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) CH2Cl2, -78 deg C, 5 min
3: CH2Cl2 / 0.5 h
4: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to 0 deg C
5: 1.) TiCl4 / 1.) Et2O, from -78 deg C to -35 deg C, 2.) Et2O, 0 deg C, 4 h
With
oxalyl dichloride; titanium tetrachloride; caesium carbonate; dimethyl sulfoxide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980542f
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / Cs2CO3 / dimethylformamide / 2 h / Ambient temperature
2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) CH2Cl2, -78 deg C, 5 min
3: CH2Cl2 / 0.5 h
4: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to 0 deg C
5: 1.) TiCl4 / 1.) Et2O, from -78 deg C to -35 deg C, 2.) Et2O, 0 deg C, 4 h
With
oxalyl dichloride; titanium tetrachloride; caesium carbonate; dimethyl sulfoxide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980542f
- Guidance literature:
-
Multi-step reaction with 3 steps
1: CH2Cl2 / 0.5 h
2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to 0 deg C
3: 1.) TiCl4 / 1.) Et2O, from -78 deg C to -35 deg C, 2.) Et2O, 0 deg C, 4 h
With
oxalyl dichloride; titanium tetrachloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
DOI:10.1021/jm980542f
