84688-14-2

Upstream product

• 100-39-0 benzyl bromide 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 201230-82-2 carbon monoxide 
• 110658-33-8 (S)-2-(1,3-dioxoisoindolin-2-yl)pent-4-enoic acid 
• 16338-48-0 L-allylglycine 
• 1228152-53-1 benzyl (S)-2-(1,3-dioxoisoindolin-2-yl)pent-4-enoate 
• 6033-32-5 (S)-2-amino-6-hydroxyhexanoic acid 
• 84688-11-9 (S)-2-(1,3-dioxoisoindolin-2-yl)-6-hydroxyhexanoic acid 
• 84688-13-1 (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester 

Downstream Products

• 182886-83-5 (S)-hexahydro-7,7-dimethyl-3-<(triphenylmethyl)amino>-2H-azepin-2-one 
• 182886-36-8 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-oxo-heptanoic acid benzyl ester 
• 197902-92-4 (S)-2-phthalimido-6-methyl-6-hydroxyheptanoic acid, phenylmethyl ester 
• 197902-93-5 (S)-2-phthalimido-6-methyl-6-azidoheptanoic acid, phenylmethyl ester 
• 160135-92-2 [14C]-Gemopatrilat 
• 160135-15-9 [S-(R*,R*)]-Hexahydro-6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid, ethyl ester 
• 182886-84-6 (S)-Hexahydro-6-[(triphenylmethyl)amino]-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid, ethyl ester 

Relevant academic research and scientific papers

Diastereoselective and Branched-Aldehyde-Selective Tandem Hydroformylation-Hemiaminal Formation: Synthesis of Functionalized Piperidines and Amino Alcohols

Starting from readily available allylglycine, a tandem hydroformylation-hemiaminal formation reaction has been developed for the synthesis of chiral functionalized piperidines, with very good diastereoselectivity and branched regioselectivity using Rh/(S,

N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors

N-formyl hydroxylamines are provided which have the structure wherein R is H, alkyl, alkenyl, aryl-(CH2)p—, heteroaryl-(CH2)p— or cycloheteroalkyl-(CH2)p— R1is H or COR2where R2is alkyl, aryl-(CH2)p—, cycloheteroalkyl-(CH2)p—, heteroaryl-(CH2)p—, alkoxy or cycloalkyl-(CH2)p—, p is 0 to 8, and A is a dipeptide derived from an amino acid or is a conformationally restricted dipeptide mimic. The above compounds are useful in treating hypertension congestive heart failure, renal failure, and hepatic cirrhosis.

Vasopeptidase inhibitors: Incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides

A series of 7-(di)alkyl and spirocyclic substituted azepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. Clear structure-activity relationships with respect to both angiotensin-converti

A synthetic route for the generation of C-7 substituted azepinones

A versatile method for the synthesis of 3-amino azepinones possessing alkyl substitution at the C-7 position is described. Compounds of this type may be viewed as conformationally restricted dipeptide surrogates.

BICYCLIC LACTAMS

The invention relates to bicyclic lactams and related compounds which are useful as antihypertensives.