methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

Base Information

Chemical Name:methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate
CAS No.:158469-84-2
Molecular Formula:C₂₇H₃₄F₃NO₅Si
Molecular Weight:537.651
Hs Code.:

Synonyms:methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

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Chemical Property of methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

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Technology Process of methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

There total 7 articles about methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1885-14-9
phenyl chloroformate

: 158469-92-2
methyl (2S)-2-<<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

: 158469-84-2
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(01)85516-2

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 158469-84-2
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 5 h / 80 °C

2: benzene / 0.5 h / Ambient temperature

3: NaBH₄ / methanol / 0 deg C, 0.2 h, then 0 deg C --> room temp., 0.5 h

4: 71 percent / sat. sodium bicarbonate / ethyl acetate; H₂O / 1 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; In methanol; water; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4020(01)85516-2

Reference yield:

: 349-95-1
4-(trifluoromethyl)benzylic alcohol

: 158469-84-2
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / pyridinium chlorochromate / CH₂Cl₂ / 2.5 h / Ambient temperature

2: toluene / 5 h / 80 °C

3: benzene / 0.5 h / Ambient temperature

4: NaBH₄ / methanol / 0 deg C, 0.2 h, then 0 deg C --> room temp., 0.5 h

5: 71 percent / sat. sodium bicarbonate / ethyl acetate; H₂O / 1 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; pyridinium chlorochromate; In methanol; dichloromethane; water; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4020(01)85516-2