trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Base Information

Chemical Name:trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide
CAS No.:1443543-98-3
Molecular Formula:C₂₂H₂₃ClF₃N₃O₃
Molecular Weight:469.891
Hs Code.:

Synonyms:trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Suppliers and Price of trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

There total 5 articles about trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1443678-49-6
t-CUCB

: 506-59-2
N,N-dimethylammonium chloride

: 1443543-98-3
trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.011

Reference yield:

: 1394011-78-9
trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

: 1443543-98-3
trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

2: sodium hydroxide / ethanol / 18 h / 20 - 90 °C / Inert atmosphere

3: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2013.05.011

Reference yield:

: 1443543-99-4
trans-1-(4-hydroxycyclohexyl)-3-(4-trifluoromethoxyphenyl)urea

: 1443543-98-3
trans-3-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 18 h / 20 - 90 °C / Inert atmosphere

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.011