tert-butyl (4-N,N-dimethylamino)phenylphosphinate

Base Information

• Chemical Name: tert-butyl (4-N,N-dimethylamino)phenylphosphinate
• CAS No.: 252980-35-1
• Molecular Formula: C₁₂H₂₀NO₂P
• Molecular Weight: 241.27
• Mol file: 252980-35-1.mol

Synonyms:tert-butyl (4-N,N-dimethylamino)phenylphosphinate

Chemical Property of tert-butyl (4-N,N-dimethylamino)phenylphosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4-N,N-dimethylamino)phenylphosphinate

There total 2 articles about tert-butyl (4-N,N-dimethylamino)phenylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4-dimethylamino-phenyl)-phosphonous acid dichloride (29972-74-5) + tert-butyl alcohol (75-65-0) → tert-butyl (4-N,N-dimethylamino)phenylphosphinate (252980-35-1)

Guidance literature:

DOI:10.1016/S0040-4039(99)01579-8

Reference yield:

N,N-dimethyl-aniline (121-69-7,77733-26-7) → tert-butyl (4-N,N-dimethylamino)phenylphosphinate (252980-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₃; pyridine / 4 h / 115 °C

2: 1.60 g / CH₂Cl₂ / 1 h / 20 °C

With pyridine; phosphorus trichloride; In dichloromethane; 1: Substitution / 2: Substitution;

DOI:10.1021/jo991246t

Reference yield: 74.0%

(S)-N,N'-di(tert-butoxycarbonyl)-1,2-diamino-(4-iodophenyl)propane (174809-61-1) + tert-butyl (4-N,N-dimethylamino)phenylphosphinate (252980-35-1) → [4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester (252980-36-2)

Guidance literature:

With triethylamine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In acetonitrile;

DOI:10.1016/S0040-4039(99)01579-8

upstream raw materials:

(4-dimethylamino-phenyl)-phosphonous acid dichloride

tert-butyl alcohol

N,N-dimethyl-aniline

Downstream raw materials:

[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester