5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one

Base Information

• Chemical Name: 5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one
• CAS No.: 552336-54-6
• Molecular Formula: C₂₈H₃₆N₂O₆
• Molecular Weight: 496.604
• Mol file: 552336-54-6.mol

Synonyms:5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one

Chemical Property of 5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one

There total 1 articles about 5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-cyclohexylpropanal (4361-28-8) + dibenzyl azodicarboxylate (2449-05-0) + acetone (67-64-1) → 5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one (552336-54-6)

Guidance literature:

With L-proline; In acetonitrile; at 20 ℃; for 96h;

DOI:10.1021/ol034333n

Reference yield:

5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one (552336-54-6) → 5-amino-6-cyclohexyl-2-methylhexane-2,4-diol

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; tetrahydrofuran / 1 h / 0 °C

2: AcOH; H₂ / Raney nickel / methanol / 20 h / 22501.8 Torr

With hydrogen; acetic acid; nickel; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/ol034333n

Reference yield:

methylmagnesium bromide (75-16-1) + 5-(N,N'-bis(benzyloxycarbonyl)hydrazino)-4-hydroxy-6-cyclohexylhexan-2-one (552336-54-6) → C29H40N2O6

Guidance literature:

In tetrahydrofuran; toluene; at 0 ℃; for 1h;

DOI:10.1021/ol034333n

upstream raw materials:

3-cyclohexylpropanal

dibenzyl azodicarboxylate

acetone