9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one

Base Information

• Chemical Name: 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one
• CAS No.: 1198770-93-2
• Molecular Formula: C₁₇H₁₅N₃O₂S
• Molecular Weight: 325.391
• Mol file: 1198770-93-2.mol

Synonyms:9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one

Chemical Property of 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one

There total 1 articles about 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl thioisocyanate (556-61-6) + 3-amino-3-phenylquinoline-2,4(1H,3H)-dione (477950-02-0) → 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one (1198770-93-2)

Guidance literature:

In 1,4-dioxane; at 0 ℃; Reflux;

DOI:10.1016/j.tet.2009.09.048

Reference yield: 74.0%

ethanol (64-17-5) + 9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one (1198770-93-2) → ethyl 2-(2,3-dihydro-3-methyl-5-phenyl-2-thioxo-1H-imidazol-4-yl)phenylcarbamate (1198771-13-9)

Guidance literature:

With acetic acid; for 1h; Reflux;

DOI:10.1016/j.tet.2009.09.048

Reference yield: 69.0%

9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one (1198770-93-2) → 4-(2-aminophenyl)-3-methyl-5-phenyl-1H-imidazole-2(3H)-thione (1198771-11-7)

Guidance literature:

9b-hydroxy-1-methyl-3a-phenyl-1,2,3,3a-tetrahydro-2-thioxo-5H-imidazo[4,5-c]quinolin-4(9bH)-one; With hydrogenchloride; In water; for 1h; Reflux;

With pyridine;

DOI:10.1016/j.tet.2009.09.048

upstream raw materials:

methyl thioisocyanate

3-amino-3-phenylquinoline-2,4(1H,3H)-dione

Downstream raw materials:

4-(2-aminophenyl)-3-methyl-5-phenyl-1H-imidazole-2(3H)-thione

1,3-bis(2-(2,3-dihydro-1-methyl-4-phenyl-2-thioxo-1H-imidazol-5-yl)phenyl)urea

ethyl 2-(2,3-dihydro-3-methyl-5-phenyl-2-thioxo-1H-imidazol-4-yl)phenylcarbamate