(1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine

Base Information

• Chemical Name: (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine
• CAS No.: 1563040-12-9
• Molecular Formula: C₁₂H₁₃N₃O
• Molecular Weight: 215.255
• Mol file: 1563040-12-9.mol

Synonyms:(1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine

Chemical Property of (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine

There total 3 articles about (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(1-imidazolyl)-3-phenyl-propan-3-one (28918-16-3) → (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine (1563040-12-9)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In ethanol; for 18h; Reflux;

DOI:10.3390/molecules181012208

Reference yield:

acetophenone (98-86-2) → (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine (1563040-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol / 2 h / Reflux

2: water / 5 h / Reflux

3: hydroxylamine hydrochloride; potassium hydroxide / ethanol / 18 h / Reflux

With hydrogenchloride; hydroxylamine hydrochloride; potassium hydroxide; In ethanol; water;

DOI:10.3390/molecules181012208

Reference yield:

3-(dimethylamino)propiophenone hydrochloride (879-72-1) → (1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine (1563040-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 5 h / Reflux

2: hydroxylamine hydrochloride; potassium hydroxide / ethanol / 18 h / Reflux

With hydroxylamine hydrochloride; potassium hydroxide; In ethanol; water;

DOI:10.3390/molecules181012208 DOI:10.3390/molecules22111895

upstream raw materials:

1-(1-imidazolyl)-3-phenyl-propan-3-one

3-(dimethylamino)propiophenone hydrochloride

acetophenone

Downstream raw materials:

(E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-benzoyl oxime

(E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime

(E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-fluorobenzoyl oxime

(E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-methylbenzoyl oxime