methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

Base Information

Chemical Name:methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester
CAS No.:474103-30-5
Molecular Formula:C₂₂H₂₆Cl₃N₃O₅S
Molecular Weight:550.891
Hs Code.:

methanesulfonic acid 2-{4-[<i>tert</i>-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

Synonyms:methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

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Chemical Property of methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

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Technology Process of methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

There total 9 articles about methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 474103-29-2
[6-chloro-5-(1-hydroxymethyl-but-3-enyl)-2-methyl-pyrimidin-4-yl]-(2,4-dichloro-phenyl)-carbamic acid tert-butyl ester

: 124-63-0
methanesulfonyl chloride

: 474103-30-5
methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2005.05.040

Reference yield:

: (4,6-dihydroxy-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester

: 474103-30-5
methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 73 percent / POCl₃ / 3.5 h / Heating

2.1: 68 percent / LiHMDS / hexane; tetrahydrofuran / 0 - 20 °C

3.1: 86 percent / DIBAl-H / hexane; CH₂Cl₂ / 3 h / -78 - 0 °C

4.1: 81 percent / imidazole / dimethylformamide / 3 h / 0 - 20 °C

5.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

5.2: 72 percent / tetrahydrofuran / 3 h / Heating

6.1: 83 percent / DMAP / CH₂Cl₂ / 18 h / 20 °C

7.1: 74 percent / Et₃N*3HF / dimethylformamide / 18 h / 20 °C

8.1: 98 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; dmap; sodium hydride; diisobutylaluminium hydride; triethylamine tris(hydrogen fluoride); triethylamine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.040

Reference yield:

: 474103-23-6
2-(4,6-dichloro-2-methyl-pyrimidin-5-yl)-pent-4-en-1-ol

: 474103-30-5
methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / imidazole / dimethylformamide / 3 h / 0 - 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

2.2: 72 percent / tetrahydrofuran / 3 h / Heating

3.1: 83 percent / DMAP / CH₂Cl₂ / 18 h / 20 °C

4.1: 74 percent / Et₃N*3HF / dimethylformamide / 18 h / 20 °C

5.1: 98 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; dmap; sodium hydride; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.040