trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Base Information

Chemical Name:trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate
CAS No.:945997-80-8
Molecular Formula:C₂₈H₃₇N₃O₃
Molecular Weight:463.62
Hs Code.:

Synonyms:trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

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Chemical Property of trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

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Technology Process of trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

There total 6 articles about trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4'-ethoxy-3'-formyl-biphenyl-4-carbonitrile

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 945997-80-8
trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Guidance literature:: 4'-ethoxy-3'-formyl-biphenyl-4-carbonitrile; trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane; With acetic acid; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; toluene; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; toluene;

Reference yield:

: 79636-94-5
5-bromo-2-ethoxybenzaldehyde

: 126747-14-6
4-cyanophenylboronic acid

: 945997-80-8
trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3.25 - 6.25 h / 20 - 105 °C

2.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

2.2: 1 h

With caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 566172-78-9
n-butyl trans-(4-aminocyclohexyl)-carbamate

: 945997-80-8
trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 18.5 h / 0 °C / Heating / reflux

1.2: 2.16 h / 0 - 20 °C

2.1: benzaldehyde / toluene / 6 h / Heating / reflux

2.2: 3.25 h / 20 °C

3.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

3.2: 1 h

With lithium aluminium tetrahydride; benzaldehyde; acetic acid; In tetrahydrofuran; toluene;