2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Base Information

Chemical Name:2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester
CAS No.:119126-23-7
Molecular Formula:C₁₈H₂₃N₅O₅
Molecular Weight:389.411
Hs Code.:

Synonyms:2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

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Chemical Property of 2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

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Technology Process of 2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

There total 4 articles about 2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 119126-26-0
1-[(dimethylamino)carbonyl]-1,6-dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester

: 119126-23-7
2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Guidance literature:: With ammonia; In ethanol; at 75 ℃; for 72h;
DOI:10.1021/jo00286a020

Reference yield:

: 118431-79-1
2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1-methylethyl ester

: 119126-23-7
2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / sodium bicarbonate / dimethylformamide / 24 h / 70 °C

2: triethylamine / CH₂Cl₂; benzene / 1.5 h / 0 °C

3: CH₂Cl₂; benzene; H₂O / 16 h / Ambient temperature

4: 40 percent / NH₃ / ethanol / 72 h / 75 °C

With ammonia; sodium hydrogencarbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00286a020

Reference yield:

: 108931-52-8
1,4-Dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester

: 119126-23-7
2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂; benzene / 1.5 h / 0 °C

2: CH₂Cl₂; benzene; H₂O / 16 h / Ambient temperature

3: 40 percent / NH₃ / ethanol / 72 h / 75 °C

With ammonia; triethylamine; In ethanol; dichloromethane; water; benzene;
DOI:10.1021/jo00286a020