118431-79-1

Basic information

• Product Name: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1-methylethyl ester
• Synonyms: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1-methylethyl ester
• CAS NO: 118431-79-1
• Molecular Weight: 277.277
• Mol File: 118431-79-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1-methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1-methylethyl ester(118431-79-1)
• EPA Substance Registry System: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1-methylethyl ester(118431-79-1)

Safety Data

• Hazardous Substances Data: 118431-79-1(Hazardous Substances Data)

Upstream product

• 542-08-5 isopropyl acetoacetate 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 108931-52-8 1,4-Dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester 
• 74936-70-2 3-(2-cyanoethyl) 5-isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 77940-90-0 (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester 
• 112795-79-6 1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid 1-methylethyl ester 
• 124711-86-0 1,2,4,7-Tetrahydro-5-methyl-7-(3-nitro-phenyl)-2-oxopyrazolo[1,5,-a]pyrimidine-6carboxylic acid, 1-methylethyl ester 
• 108932-01-0 1,4-Dihydro-2-[[(4-methoxyphenyl)methyl]-thio]-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, 1-methylethyl ester, monohydrochloride 
• 832075-56-6 3,6-dihydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1,5(2H)-pyrimidinedicarboxylic acid 5-(1-methylethyl) 1-<(S)-1-methyl-2-ethyl> diester 
• 123486-15-7 1,2,3,6-tetrahydro-2-imino-4-methyl-6-(3-nitrophenyl)-1-(2-propenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester 
• 119126-26-0 1-[(dimethylamino)carbonyl]-1,6-dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester 
• 119126-23-7 2-amino-1,6-dihydro-4-methyl-1-<(dimethylamino)carbonyl>-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester 
• 110887-93-9 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(2-propenyl)-5-pyrimidinecarboxylic acid, 1-methylethyl ester 
• 123486-14-6 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-1-(2-propenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester 
• 110887-87-1 1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-(2-propenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester 
• 123505-60-2 1,2,3,4-tetrahydro-6-methyl-4-(3-nitrophenyl)-2-oxo-1-(2-propenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester 

Relevant articles and documents

Identification and synthesis of impurities formed during preparation of azelnidipine

Azelnidipine (1), dihydropyridine-based calcium antagonists (DHPs) are one of the widely used drugs for treatment of hypertension. During the laboratory optimization and later during its bulk synthesis the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation patterns in LC-MS. Most of the impurities were synthesized and their assigned constitutions confirmed by co-injection in HPLC. We describe herein the formation, synthesis and characterization of these impurities. Our study will be of immense help to others to obtain chemically high pure azelnidipine.