5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

Base Information

Chemical Name:5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester
CAS No.:952019-90-8
Molecular Formula:C₁₈H₁₅Cl₃O₄
Molecular Weight:401.674
Hs Code.:

Synonyms:5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

Chemical Property:

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Technology Process of 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

There total 3 articles about 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 17392-83-5,2155-30-8
(R)-Methyl lactate

: 654682-18-5
1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)ethanone

: 952019-90-8
5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

Guidance literature:: 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)ethanone; With sodium hydride; In tetrahydrofuran; for 0.25h;

(R)-Methyl lactate; In tetrahydrofuran; at 20 ℃; for 18h; Further stages.;
DOI:10.1080/00397910701481237

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 952019-90-8
5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 59 percent / diethyl ether

2.1: NaH / tetrahydrofuran / 0.25 h

2.2: 47 percent / tetrahydrofuran / 18 h / 20 °C

With sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1080/00397910701481237

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 952019-90-8
5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂

2.1: 59 percent / diethyl ether

3.1: NaH / tetrahydrofuran / 0.25 h

3.2: 47 percent / tetrahydrofuran / 18 h / 20 °C

With pyridine; sodium hydride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1080/00397910701481237