654682-18-5

Basic information

• Product Name: 1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)ethanone
• Synonyms: 1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)ethanone;4'-Chloro-2-(2,4-dichlorophenyl)acetophenone
• CAS NO: 654682-18-5
• Molecular Formula: C₁₄H₉Cl₃O
• Molecular Weight: 299.57966
• Mol File: 654682-18-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 127-128.5 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 419.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.377±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)ethanone(654682-18-5)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)ethanone(654682-18-5)

Safety Data

• Hazardous Substances Data: 654682-18-5(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)ethanone, also known as diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce pain and inflammation in conditions such as arthritis, acute gout, and postoperative pain. It works by inhibiting the production of inflammatory chemicals in the body, such as prostaglandins. Diclofenac is available in several forms, including oral tablets, topical gels, and eye drops. While generally well-tolerated, diclofenac can cause side effects such as stomach upset, dizziness, and skin irritation. Long-term use of diclofenac may increase the risk of heart attacks and strokes, particularly in those with pre-existing heart conditions. As with all medications, it is important to use diclofenac under the guidance of a healthcare professional and to adhere to the prescribed dosage and duration of treatment.

Upstream product

• 66985-46-4 (+/-)-2-(4-chlorophenyl)-2-(trimethylsiloxy)-acetonitrile 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 19719-28-9 2,4-dichlorophenylacetic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 129752-86-9 2,4-dichlorobenzyl-magnesium chloride 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 108-90-7 chlorobenzene 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 796875-12-2 2-bromo-1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)ethanone 
• 952019-90-8 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxy-5-oxo-pentanoic acid methyl ester 
• 904706-24-7 3-chloro-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)acrylaldehyde 
• 113193-63-8 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)prop-2-en-1-one 
• 98617-28-8 [2,4-dichloro-α-(1,2,4-triazolylmethyl)benzyl]-(4-chlorophenyl)-ketone 
• 875667-63-3 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-methyl-1H-pyrrole-2-carboxylic acid 
• 952019-94-2 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 952019-92-0 5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-2,5-dioxo-pentanoic acid methyl ester 
• 721399-91-3 ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1,3-thiazole-2-carboxylate 
• 96223-59-5 1-[(4R,5S)-5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-2-oxo-2λ⁴-[1,3,2]dioxathiolan-4-ylmethyl]-1H-[1,2,4]triazole 
• 96223-59-5 1-[(4R,5R)-5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-2-oxo-2λ⁴-[1,3,2]dioxathiolan-4-ylmethyl]-1H-[1,2,4]triazole 
• 96223-41-5 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3-dioxolane 
• 96223-41-5 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-4-<(1H-1,2,4-triazol-1-yl)methyl>1,3-dioxolane 
• 93363-60-1 (threo)-1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propylene glycol 

Relevant articles and documents

N-[(4,5-DIPHENYL-2-THIENYL)METHYL]AMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The subject of the present invention is compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.

DIPHENYLPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF

The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I): where: R1 represents hydrogen or a (C1-C 4)alkyl; R2 represents: a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1-C4)alkanoyl; NR10R11; a nonaromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4)alkyl; a nonaromatic (C11-C12) carbocycle unsubstituted or mono-or polysubstituted with (C1-C4) alkyl; a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4)alkyl; or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin- 1-yl group; the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described