N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

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Chemical Name:N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide
CAS No.:916052-96-5
Molecular Formula:C₂₃H₁₈ClN₅O₂S
Molecular Weight:463.947
Hs Code.:

Synonyms:N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

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Chemical Property of N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

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Technology Process of N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

There total 7 articles about N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: N-(3-amino-2-chlorophenyl)cyclobutanecarboxamide

: 916052-15-8
(5Z)-2-(methylthio)-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one

: 916052-96-5
N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

Guidance literature:: In valeric acid; at 140 ℃; for 0.666667h;

Reference yield:

: 130345-50-5
quinoxaline-6-carbaldehyde

: 916052-96-5
N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / acetic acid / 18 h / Heating / reflux

2: triethylamine / ethanol / 4 h / 20 °C

3: valeric acid / 0.67 h / 140 °C

With sodium acetate; triethylamine; In ethanol; acetic acid; valeric acid;

Reference yield:

: 6344-72-5
6-methylquinoxaline

: 916052-96-5
N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: selenium(IV) oxide / 1,4-dioxane / 3 h / 220 °C / Microwave heating

2: sodium acetate / acetic acid / 18 h / Heating / reflux

3: triethylamine / ethanol / 4 h / 20 °C

4: valeric acid / 0.67 h / 140 °C

With selenium(IV) oxide; sodium acetate; triethylamine; In 1,4-dioxane; ethanol; acetic acid; valeric acid;