[(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester
CAS No.:228262-83-7
Molecular Formula:C₂₈H₃₇NO₄
Molecular Weight:451.606
Hs Code.:

Synonyms:[(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

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Chemical Property of [(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

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Technology Process of [(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

There total 5 articles about [(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 228262-77-9
(1S,2R)-2-((S)-1-Methyl-2-oxo-ethyl)-cyclopentanecarboxylic acid methyl ester

: 228262-83-7
[(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / NaBH₄ / methanol / 1 h / 0 °C

2: 93 percent / PPh₃, diethyl azodicarboxylate / tetrahydrofuran / 2 h / 80 °C

3: 69 percent / LDA / tetrahydrofuran / -78 deg C to RT, 22 h

4: 89 percent / 2M KOH / H₂O; dimethylsulfoxide / 7.5 h / 120 °C

5: DPPA, Et₃N / benzene / 2 h / Heating

6: iPr₂NEt / benzene / 15 h / Heating

With potassium hydroxide; sodium tetrahydroborate; diphenyl-phosphinic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(99)00578-X

Reference yield:

: 228262-78-0
(1S,2R)-2-((S)-2-Hydroxy-1-methyl-ethyl)-cyclopentanecarboxylic acid methyl ester

: 228262-83-7
[(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / PPh₃, diethyl azodicarboxylate / tetrahydrofuran / 2 h / 80 °C

2: 69 percent / LDA / tetrahydrofuran / -78 deg C to RT, 22 h

3: 89 percent / 2M KOH / H₂O; dimethylsulfoxide / 7.5 h / 120 °C

4: DPPA, Et₃N / benzene / 2 h / Heating

5: iPr₂NEt / benzene / 15 h / Heating

With potassium hydroxide; diphenyl-phosphinic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; water; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(99)00578-X

Reference yield:

: 228262-79-1
(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-cyclopentanecarboxylic acid methyl ester

: 228262-83-7
[(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / LDA / tetrahydrofuran / -78 deg C to RT, 22 h

2: 89 percent / 2M KOH / H₂O; dimethylsulfoxide / 7.5 h / 120 °C

3: DPPA, Et₃N / benzene / 2 h / Heating

4: iPr₂NEt / benzene / 15 h / Heating

With potassium hydroxide; diphenyl-phosphinic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; water; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(99)00578-X