2-Amino-5-bromo-3-methoxybenzonitrile

Base Information

Chemical Name:2-Amino-5-bromo-3-methoxybenzonitrile
CAS No.:176718-54-0
Molecular Formula:C₈H₇BrN₂O
Molecular Weight:227.06
Hs Code.:
European Community (EC) Number:858-659-2

Synonyms:2-amino-5-bromo-3-methoxybenzonitrile;176718-54-0;SCHEMBL2658509;LTAUXXMHNXMZJB-UHFFFAOYSA-N;MFCD22570412;BS-53355;CS-0161447

Suppliers and Price of 2-Amino-5-bromo-3-methoxybenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-Amino-5-bromo-3-methoxybenzonitrile

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:225.97418
Heavy Atom Count:12
Complexity:201

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1N)C#N)Br

Technology Process of 2-Amino-5-bromo-3-methoxybenzonitrile

There total 12 articles about 2-Amino-5-bromo-3-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 1227361-07-0
C₈H₉BrN₂O₂

: 176718-54-0
2-amino-3-methoxy-5-bromobenzonitrile

Guidance literature:: With phosphorus pentoxide; In toluene; at 110 ℃; for 1h; Solvent; Temperature;

Reference yield: 88.0%

: 148932-68-7
3-methoxy-2-aminobenzonitrile

: 176718-54-0
2-amino-3-methoxy-5-bromobenzonitrile

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5.16667h;
DOI:10.1002/anie.201904030

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 176718-54-0
2-amino-3-methoxy-5-bromobenzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: 3 h / 60 °C

2.1: acetic acid; iron / ethanol; water / 6 h / 80 °C

3.1: sodium sulfate; hydrogenchloride / water; 1,4-dioxane / 0.17 h / 50 °C

3.2: 6 h / 80 °C

4.1: sulfuric acid / 1 h / 40 °C

5.1: sodium hydroxide; dihydrogen peroxide / 1 h / 60 °C

6.1: thionyl chloride / chloroform / 3 h / 60 °C

7.1: ammonium hydroxide / 0.5 h / 20 °C

8.1: phosphorus pentoxide / toluene / 1 h / 110 °C

With hydrogenchloride; ammonium hydroxide; thionyl chloride; phosphorus pentoxide; sulfuric acid; dihydrogen peroxide; iron; acetic acid; sodium sulfate; sodium hydroxide; In 1,4-dioxane; ethanol; chloroform; water; toluene;